Dimethylformamide → (R)-N-(5-cyano-4-((1-methoxypropan-2-yl)oxy)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

HRID 1778108ノート

反応式

HRID 1778108 の反応式
C1(O[C:8](=[O:24])[NH:9][C:10]2[CH:15]=[C:14]([O:16][C@H:17]([CH3:21])[CH2:18][O:19][CH3:20])[C:13]([C:22]#[N:23])=[CH:12][N:11]=2)C=CC=CC=1.C(C1C=CC(NC([N:36]2C[CH2:41][CH2:40][CH2:39][C:38]3[CH:43]=[CH:44][C:45]([CH:47]([O:50]C)OC)=[N:46][C:37]2=3)=O)=NC=1)#N.[CH3:52][N:53]([CH:55]=[O:56])[CH3:54]>>[C:22]([C:13]1[C:14]([O:16][C@H:17]([CH3:21])[CH2:18][O:19][CH3:20])=[CH:15][C:10]([NH:9][C:8]([N:36]2[C:37]3[C:38](=[CH:43][C:44]([CH2:52][N:53]4[CH2:54][CH2:54][N:53]([CH3:55])[CH2:52][C:55]4=[O:56])=[C:45]([CH:47]=[O:50])[N:46]=3)[CH2:39][CH2:40][CH2:41]2)=[O:24])=[N:11][CH:12]=1)#[N:23]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 118037151N-(5-cyanopyridin-2-yl)-2-(dimethoxymethyl)-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamideHCID 131734794(R)-phenyl (5-cyano-4-((1-methoxypropan-2-yl)oxy)pyridin-2-yl)carbamate

生成物 1

HCID 118036293(R)-N-(5-cyano-4-((1-methoxypropan-2-yl)oxy)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

実験手順

From intermediates 145 and 81, coupled in an analogous manner to intermediate 236, but using DMF instead of THF, and deprotected in an analagous manner to Example 201. The title compound was obtained as an off-white solid.

出典と根拠

ORDレコード
ord-606bc842ff6646f08f009e48ac2348c7
出典データセット
uspto-grants-2016_02
特許番号
US09266883B2

反応ノート

読み込み中…