Dimethylformamide → (S)-N-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-7-formyl-2-methyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

HRID 1778110ノート

反応式

HRID 1778110 の反応式
C1(O[C:8](=[O:23])[NH:9][C:10]2[CH:15]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[C:13]([C:21]#[N:22])=[CH:12][N:11]=2)C=CC=CC=1.C(C1C=CC(NC([N:35]2[CH2:41][CH2:40][CH2:39][CH2:38][C:37]3[CH:42]=[CH:43][C:44]([CH:46]([O:49]C)OC)=[N:45][C:36]2=3)=O)=NC=1)#N.[CH3:51][N:52]([CH:54]=[O:55])[CH3:53]>>[C:21]([C:13]1[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:15][C:10]([NH:9][C:8]([N:35]2[C:36]3[C:37](=[CH:42][C:43]([CH2:51][N:52]4[CH2:53][CH2:53][N:52]([CH3:54])[CH2:51][C:54]4=[O:55])=[C:44]([CH:46]=[O:49])[N:45]=3)[CH2:38][CH2:39][C@@H:41]2[CH3:40])=[O:23])=[N:11][CH:12]=1)#[N:22]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 118037151N-(5-cyanopyridin-2-yl)-2-(dimethoxymethyl)-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamideHCID 125470569Phenyl (5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)carbamate

生成物 1

HCID 118036665(S)-N-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-7-formyl-2-methyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

実験手順

From intermediates 108 and 268, coupled and deprotected in an analogous manner to intermediate 236, but using DMF instead of THF, and Example 201. The title compound was obtained as a light yellow-brown solid.

出典と根拠

ORDレコード
ord-67dfb88aeb8f4121874dfd0f4b79f165
出典データセット
uspto-grants-2016_02
特許番号
US09266883B2

反応ノート

読み込み中…