Dimethylformamide → (S)-N-(5-cyano-4-isopropoxypyridin-2-yl)-7-formyl-2-methyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
反応式
C1(O[C:8](=[O:22])[NH:9][C:10]2[CH:15]=[C:14]([O:16][CH:17]([CH3:19])[CH3:18])[C:13]([C:20]#[N:21])=[CH:12][N:11]=2)C=CC=CC=1.C(C1C=CC(NC([N:34]2[CH2:40][CH2:39][CH2:38][CH2:37][C:36]3[CH:41]=[CH:42][C:43]([CH:45]([O:48]C)OC)=[N:44][C:35]2=3)=O)=NC=1)#N.[CH3:50][N:51]([CH:53]=[O:54])[CH3:52]>>[C:20]([C:13]1[C:14]([O:16][CH:17]([CH3:18])[CH3:19])=[CH:15][C:10]([NH:9][C:8]([N:34]2[C:35]3[C:36](=[CH:41][C:42]([CH2:50][N:51]4[CH2:52][CH2:52][N:51]([CH3:53])[CH2:50][C:53]4=[O:54])=[C:43]([CH:45]=[O:48])[N:44]=3)[CH2:37][CH2:38][C@@H:40]2[CH3:39])=[O:22])=[N:11][CH:12]=1)#[N:21]参加物
4
反応物 3
生成物 1
実験手順
From intermediates 96 and 268, coupled and deprotected in an analogous manner to intermediate 236, but using DMF instead of THF, and Example 201. The title compound was obtained as a light brown solid.