Trimethyl orthoacetate → HCID 86719150、化合物
反応式
[Br:1][C:2]1[N:3]=[C:4]([Cl:10])[C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[C:11](OC)(OC)(OC)[CH3:12]>O>[Br:1][C:2]1[N:3]=[C:4]([Cl:10])[C:5]2[N:6]([C:11]([CH3:12])=[N:9][N:8]=2)[CH:7]=1参加物
4
反応条件
- 温度
- 130 °C
実験手順
5-bromo-3-chloro-2-hydrazinylpyrazine 1′-1 (945 mg; 3.51 mmol) is dissolved in 12 ml trimethyl orthoacetate and heated up to 130° C. for 1 hour. The solution is diluted with water and extracted with EtOAc. The organic phase is then purified with flash chromatography: cHex/EtOAc=70%/30% to 55%/45% within 10 column volumes.
後処理
- extractionextracted with EtOAc
- customThe organic phase is then purified with flash chromatography
出典と根拠
- ORDレコード
- ord-8153cb52768c4ee89ccf5b14ef7f701e
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266891B2
反応ノート
読み込み中…