3,4-Difluorobenzaldehyde → 4-(3,4-Difluoro-phenyl)-6-methyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2Cl)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4].[F:25]C1C=C(C=CC=1F)C=O>>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[C:19]([F:25])[CH:18]=2)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4]参加物
3
実験手順
Compound D was prepared in analogy to Compound B with the procedure shown in Scheme 3 by using 3,4-difluoro-benzaldehye instead of 2-chloro-5-fluorobenzaldehyde.
出典と根拠
- ORDレコード
- ord-d245d62f3c734af9934790bd54f68b6a
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266904B2
反応ノート
読み込み中…