4-Aminotetrahydropyran → 5-bromo-2-(tetrahydro-2H-pyran-4-yl)isoindolin-1-one

HRID 1778746ノート

反応式

HRID 1778746 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[NH2:13][CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:13]([CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[CH2:11]2

参加物

3

反応物 2

HCID 4192234-AminotetrahydropyranHCID 231581454-Bromo-2-(bromomethyl)benzoate

生成物 1

HCID 867228435-bromo-2-(tetrahydro-2H-pyran-4-yl)isoindolin-1-one

実験手順

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate (AstaTech Cat. No. 27012) and 4-aminotetrahydropyran (Aldrich Cat No. 711357). LCMS (M+H)+=296.0/298.0.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-005a41558219478cb26bb7bafc6997b9
出典データセット
uspto-grants-2016_02
特許番号
US09266892B2

反応ノート

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