Triethylamine → 4-Bromo-1-methyl-2-phenoxybenzene
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([OH:8])[CH:7]=1.[C:10]1(B(O)O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>ClCCl.C(OCC)(=O)C.CC([O-])=O.CC([O-])=O.[Cu+2]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([O:8][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1参加物
7
実験手順
A mixture of 5-bromo-2-methylphenol (1.0 g), phenylboronic acid (1.30 g), Cu(OAc)2 (0.97 g), and triethylamine (2.98 mL) in dichloromethane (50 mL) was stirred for 4 days. The mixture was diluted with ethyl acetate, washed four times with 1M aqueous NaOH solution and once with brine, dried over Na2SO4, filtered, and concentrated. The crude product was chromatographed on silica gel using 2% ethyl acetate in hexanes to afford the title compound.
後処理
- washwashed four times with 1M aqueous NaOH solution
- dry with materialonce with brine, dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customThe crude product was chromatographed on silica gel using 2% ethyl acetate in hexanes
出典と根拠
- ORDレコード
- ord-6f1b778d47ee44d0a90a5bf0da19b7bc
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266877B2
反応ノート
読み込み中…