3-Benzyloxybenzyl bromide → 2(R)-isopropyl-3-(3-benzyloxyphenyl)-propanol

HRID 1779793

反応式

C(NC(=O)[C@H](C)C[C@H](O)[C@@H](NC(OC(C)(C)C)=O)C[C@@H](C(C)C)[CH2:13][C:14]1[CH:19]=CC=[C:16]([OH:20])[CH:15]=1)CCC.C(OC1C=C(C=CC=1C(C)(C)C)CBr)(=O)C.[CH2:51]([O:58][C:59]1[CH:60]=[C:61]([CH:64]=[CH:65][CH:66]=1)[CH2:62]Br)[C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1>ClCCl.CCCCCC>[CH:14]([C@@H:15]([CH2:62][C:61]1[CH:64]=[CH:65][CH:66]=[C:59]([O:58][CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)[CH:60]=1)[CH2:16][OH:20])([CH3:19])[CH3:13]

参加物

実験手順

The N-tert-butoxycabonyl-2(R)-methyl-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(3-hydroxyphenyl)-octanoic acid (N-butyl)-amide used as starting material is prepared analogously to Example 5a)-5l), except that in step k) instead of 3-acetoxy-4-tert-butyl-benzyl bromide there is used 3-benzyloxy-benzyl bromide, so that in step i) 2(R)-isopropyl-3-(3-benzyloxy-phenyl)-propanol, Rf (dichloromethane/hexane=1:1)=0.19, is obtained directly.

出典と根拠

ORDレコード: ord-16e1ac8d9a2c46bf8bf85e9d5db6072d
出典データセット: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05627182

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

出典と根拠

関連ノート