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Benzyl Bromide → 1-Benzyl-N-tert-butylcyclopropane-1-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | N-tert-butyl-1-methylcyclopropane-1-sulfonamide | HCID 21889792 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 1-Benzyl-N-tert-butylcyclopropane-1-sulfonamide | HCID 21889796 | 60% |
反応手順
This compound was obtained in 60% yield using the procedure described for the synthesis of N-tert-butyl-(1-methyl)cyclopropylsulfonamide except 1.05 equivalents of benzyl bromide were used, followed by trituration with 10% EtOAc in hexane: 1H NMR (CDCl3) δ 0.92 (m, 2H), 1.36 (m, 2H), 1.43 (s, 9H), 3.25 (s, 2H), 4.62 (bs, 1H), 7.29-7.36 (m, 5H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741281B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-40d10a06071841418c8581ff2279cdcf |
| 出典メモ | uspto-grants-2010_06 |