1,4-Dioxane → (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxypropanoic acid
反応式
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C@@H:19]([CH2:24][O:25][CH3:26])[C:20]([O:22]C)=[O:21])=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.O1CCOCC1>>[CH:10]1[C:11]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C@@H:19]([CH2:24][O:25][CH3:26])[C:20]([OH:22])=[O:21])=[O:17])[C:13]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[C:6]=2[CH:7]=[CH:8][CH:9]=1参加物
3
実験手順
To a solution of methyl (S)-(9-fluorenylmethyloxycarbonylamino)-3-methoxypropionate (2.18 g, 6.13 mmol) in dioxane (31 ml) 6M HCl (31 ml, 184 mmol) was added. This mixture was allowed to cool down and concentrated. The residue was purified by flash chromatography (silica gel; hexane: ethyl acetate: acetic acid (10:10:1).
後処理
- temperatureto cool down
- concentrationconcentrated
- customThe residue was purified by flash chromatography (silica gel