N-(4-Chlorophenyl)-3-phenylacrylamide → 5-Chloroquinolin-2(1h)-one

HRID 1780746

反応式

HRID 1780746 の反応式
ClC1C=CC([NH:8][C:9](=[O:18])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=CC=1.[Cl-:19].[Al+3].[Cl-].[Cl-]>ClC1C=CC=CC=1>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:12]=1[CH:11]=[CH:10][C:9](=[O:18])[NH:8]2

参加物

4

反応物 2

HCID 303259N-(4-Chlorophenyl)-3-phenylacrylamideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 122780365-Chloroquinolin-2(1h)-one

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
125 °C

実験手順

To a mixture of N-(4-chlorophenyl)cinnamamide (8.3 g), and chlorobenzene (60 ml) was added portionwise aluminum chloride (21.4 g) under nitrogen at room temperature and the reaction mixture was slowly warmed up to 125° C. and kept at that temperature for 3 hours. The reaction mixture was cooled down and poured over 400 g of ice. The product crystallized out as a pink solid which was filtered and dried.

後処理

  1. temperatureThe reaction mixture was cooled down
  2. customThe product crystallized out as a pink solid which
  3. filtrationwas filtered
  4. customdried

出典と根拠

ORDレコード
ord-caeb36afcb1a4a7a81c6fa5431263e1b
出典データセット
uspto-grants-1997_05
特許番号
US05631254

関連ノート

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