1-(2-pyridyl)-1-[2,6-di(tetrahydro-2H-2-pyranyloxymethyl)phenyl]-methanol → 1-(2-Pyridyl)-1-[2,6-di(hydroxymethyl)-phenyl]methanol
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([C:9]1[C:14]([CH2:15][O:16]C2CCCCO2)=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:23][O:24]C1CCCCO1)[OH:8]>C(O)(=O)C.C1COCC1.O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([C:9]1[C:10]([CH2:23][OH:24])=[CH:11][CH:12]=[CH:13][C:14]=1[CH2:15][OH:16])[OH:8]参加物
3
実験手順
A solution of 1 g (2.42 mmol) of 1-(2-pyridyl)-1-[2,6-di(tetrahydro-2H-2-pyranyloxymethyl)phenyl]-methanol in 14 ml of acetic acid/THF/water (4:2:1) was heated at 100° C. under nitrogen for 6 hours. The mixture was concentrated in vacuo, the residue was dissolved in ethyl acetate and concentrated in vacuo. The residual solid was triturated with ether to afford 0.26 g of 1-(2-pyridyl)-1-[2,6-di(hydroxymethyl)-phenyl]methanol (Formula X: R1 =R2 =H; R7 =6-hydroxymethyl) as a solid.