化工社化工社 化学情報印刷レポート · 研究参考用
Propylene Oxide → 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propylene Oxide | HCID 6378 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane | HCID 107830 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid | HCID 60715 | 96% |
反応手順
To a solution of 194.0 g (0.56 mol) of 15 in 450 mL of water is added sufficient NaOH to adjust the pH to 12.0 to 12.5 (the temperature is maintained below 30° C. during the addition). Propylene oxide (65 g, 1.12 mols) is added to the basic solution. After 6 hours at ambient temperature the excess propylene oxide and solvent is removed under reduced pressure. The product is precipitated from a minimal amount of methanol to afford 16 in 96% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05631368 |
| 出典データセット | uspto-grants-1997_05 |
| ORD ID | ord-de6058ab8e8a475cb7537815b0489c23 |
| 出典メモ | uspto-grants-1997_05 |