Phenethylamine → Methyl 2-(phenethylamino)acetate
反応式
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13]>C1(C)C=CC=CC=1>[C:1]1([CH2:7][CH2:8][NH:9][CH2:11][C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
To a stirred solution of 2-phenylethylamine (9.68 g, 40 mmol) in toluene (50 mL) was added methyl bromoacetate (6.12 g, 20 mmol) dropwise at room temperature and was left stirring for 18 hours. The reaction mixture was filtered before removing the solvent in vacuo and the residue was purified by chromatography over silica gel to yield 4.8 g (61%) of the title compound as an oil. NMR (250 MHz, CDCl3) δ(1H, s), 2.92 (4H, m), 3.43 (2H, s), 3.71 (3H, s), 7.27 (5H, m).
後処理
- waitwas left
- filtrationThe reaction mixture was filtered
- custombefore removing the solvent in vacuo
- customthe residue was purified by chromatography over silica gel
出典と根拠
- ORDレコード
- ord-3c31591d8d9c4f3eb5de5bcf47f0d752
- 出典データセット
- uspto-grants-1997_05
- 特許番号
- US05631281
反応ノート
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