関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | 1,2-Diaminobenzene (D4, 98%) | HCID 10772950 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Potassium Carbonate | HCID 11430 | — |
| 生成物 | 4-(1H-1,3-benzodiazol-2-yl)aniline | HCID 345677 | 88.2% |
反応手順
This intermediate was prepared according to the procedure given in E. Acalade et al., J. Org. Chem. 52:5009-15 (1987). A mixture of 3.21 g (0.0247 moles) of O-phenylenediamine, 3.93 g (0.0287 moles) of 4-aminobenzoic acid and 42 g of polyphosphoric acid was heated to 195° C. for 5 hours. After cooling to room temperature, the reaction mixture was diluted with 180 mL of water and basified to pH 8 with solid potassium carbonate. The resulting precipitate was collected, washed with water and dried to give 4.56 g of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05633388 |
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| 出典データセット | uspto-grants-1997_05 |
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| ORD ID | ord-746b64fc659346af9a237e1ab8e9af1a |
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| 出典メモ | uspto-grants-1997_05 |
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