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N-Hydroxyacetamidine → N'-[(3,4-dimethoxy-5-nitrobenzoyl)oxy]acetamidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Hydroxyacetamidine | HCID 30926 | — |
| 反応物 | 1-(3,4-Dimethoxy-5-nitrobenzoyl)imidazole | HCID 21459020 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N'-[(3,4-dimethoxy-5-nitrobenzoyl)oxy]acetamidine | HCID 53789064 | — |
反応手順
10.0 g of 1-(3,4-dimethoxy-5-nitrobenzoyl)imidazole in 50 ml of dimethylformamide are treated with 6.95 g of acetamidoxime, whereupon the mixture is stirred at 70° for 1 hour. After cooling, the mixture is poured into 500 ml of ice-water and stirred for 30 minutes. The separated crystals are filtered under suction and washed with water. After crystallization from ethyl acetate there is obtained N'-[(3,4-dimethoxy-5-nitrobenzoyl)oxy]acetamidine in the form of colorless crystals of m.p. 165°-166°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05633371 |
| 出典データセット | uspto-grants-1997_05 |
| ORD ID | ord-9c8ea385d239420da9833029a29b5b54 |
| 出典メモ | uspto-grants-1997_05 |