Methylhydrazine → HCID 23084651、化合物

HRID 1783300ノート

反応式

HRID 1783300 の反応式
[C:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[C:5]#[N:6])(=O)[CH3:2].[CH3:14][NH:15][NH2:16]>C(O)C>[NH2:6][C:5]1[N:15]([CH3:14])[N:16]=[C:1]([CH3:2])[C:4]=1[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 30138862-(4-Fluorophenyl)-3-oxobutanenitrile

生成物 1

HCID 23084651HCID 23084651、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

α-Acetyl-4-fluorophenylacetonitrile (65.1 g) and methylhydrazine (30.9 mL) were dissolved in ethanol (320 mL), and the mixture was heated under reflux for 3 hrs. After the completion of the reaction, the reaction mixture was cooled to room temperature, and the solvent was evaporated. The obtained solid was collected by filtration and washed with hexane to give 5-amino-4-(4-fluorophenyl)-1,3-dimethylpyrazole (69.5 g).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customAfter the completion of the reaction
  4. customthe solvent was evaporated
  5. filtrationThe obtained solid was collected by filtration
  6. washwashed with hexane

出典と根拠

ORDレコード
ord-cddb9af07abf41b494cfeb8ed3d46cb9
出典データセット
uspto-grants-2009_03
特許番号
US07501412B2

反応ノート

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