化工社化工社 化学情報印刷レポート · 研究参考用
Acetonitrile → 2-[4-(4-tert-Butylbenzyl)piperazin-1-yl]-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-Cinnamylpiperazine | HCID 726896 | — |
| 反応物 | 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22379151 | — |
| 生成物 | 2-[4-(4-tert-Butylbenzyl)piperazin-1-yl]-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22378962 | — |
反応手順
To a stirred solution of 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (0.80 g in 40 ml acetonitrile) was added [(2E)-3-phenylprop-2-enyl]piperazine (0.50 g in 10 ml acetonitrile). After 3 hrs, N,N-diisopropylethylamine was added (428 μl in 10 ml acetonitrile) and the reaction stirred for a further 2 hrs after which time a precipitate of the title compound appeared. This was used crude in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07501407B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-672ef598fb674a0f9bd424ca5278f4f3 |
| 出典メモ | uspto-grants-2009_03 |