4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid
反応式
C([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([NH:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[S:21][CH:22]=[CH:23][N:24]=3)[CH:16]=[CH:15][N:14]=2)[CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:25])=[O:3])=[CH:6][C:7]=1[NH:12][C:13]1[N:18]=[C:17]([NH:19][C:20]2[S:21][CH:22]=[CH:23][N:24]=2)[CH:16]=[CH:15][N:14]=1参加物
3
実験手順
4-methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 15 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.
出典と根拠
- ORDレコード
- ord-01f82e3b9f2b4781b050a0f646eb76bd
- 出典データセット
- uspto-grants-2009_03