4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-[4-(Thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid
反応式
C([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[N:17]=[C:16]([NH:18][C:19]3[S:20][CH:21]=[CH:22][N:23]=3)[CH:15]=[CH:14][N:13]=2)=[CH:7][CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[S:20]1[CH:21]=[CH:22][N:23]=[C:19]1[NH:18][C:16]1[CH:15]=[CH:14][N:13]=[C:12]([NH:11][C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:24])=[O:3])=[CH:10][CH:9]=2)[N:17]=1参加物
3
実験手順
4-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 16 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.
出典と根拠
- ORDレコード
- ord-8c9b23c6a59349498e1b6178ffc413a0
- 出典データセット
- uspto-grants-2009_03
- DOI