Methylamine → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrile
反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1.[CH3:12][NH2:13]>C(OCC)C>[CH3:12][NH:13][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1参加物
4
実験手順
Through a 5° C. solution of 14.5 g (78.1 mmol) of 4-chloro-2-(methylthio)-5-pyrimidinecarbonitrile in 800 mL of diethyl ether is bubbled methylamine gas for a period of 15 minutes. The reaction mixture is allowed to warm to room temperature, set overnight, and filtered. The solids are washed with diethyl ether, then efficiently with 50 mL of water, and dried to give 12.0 g (81%) of the title compound: mp 189-190° C.
後処理
- filtrationfiltered
- washThe solids are washed with diethyl ether
- dry with materialefficiently with 50 mL of water, and dried
出典と根拠
- ORDレコード
- ord-55f2d7808cfe4103af4db6dfb4d082d3
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07501425B1
反応ノート
読み込み中…