Potassium Carbonate → HCID 16788087、化合物

HRID 1783751ノート

反応式

HRID 1783751 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[N:11]1(C(O)=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[C:20]([O-])([O-:22])=[O:21].[K+].[K+].CN1C(=O)CCC1>O>[N+:8]([C:7]1[C:2]([N:11]2[CH2:12][CH2:13][CH:14]([C:20]([OH:22])=[O:21])[CH2:15][CH2:16]2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 796132-Chloro-3-nitropyridineHCID 9964094Piperidine-1-carboxylic acid

生成物 1

HCID 16788087HCID 16788087、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
80 °C

実験手順

The mixture consisting of 634 mg of 2-chloro-3-nitropyridine, 620 mg of piperidine carboxylic acid, 820 mg of potash and 3 ml of NMP was stirred at 80° C. for 2 hours. After allowing to cool, 30 ml of water of water were added and the crude product was extracted with 30 ml of ethyl acetate. After drying the organic phase with sodium sulfate, it was concentrated under reduced pressure.

後処理

  1. temperatureto cool
  2. extractionthe crude product was extracted with 30 ml of ethyl acetate
  3. dry with materialAfter drying the organic phase with sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-167c65b36ef045c2878dd95c113c12bc
出典データセット
uspto-grants-2009_03
特許番号
US07501440B2

反応ノート

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