Stannous Chloride → 4-Piperidinecarboxylic acid, 1-(3-amino-2-pyridinyl)-

HRID 1783752ノート

反応式

HRID 1783752 の反応式
[N+:1]([C:4]1[C:5]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[Sn](Cl)Cl>C(OCC)(=O)C>[NH2:1][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 24479Stannous ChlorideHCID 16788087HCID 16788087、化合物

生成物 1

HCID 690784654-Piperidinecarboxylic acid, 1-(3-amino-2-pyridinyl)-

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The solution of 850 mg of 3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid in 40 ml of ethyl acetate was admixed with 2.3 g of tin(II) chloride and stirred at room temperature for 3 hours. The mixture was then extracted with 50 ml of water, the aqueous phase was adjusted to pH=6 using sodium dihydrogenphosphate and the product was extracted with ethyl acetate. After drying the organic phase over sodium sulfate, it was concentrated under reduced pressure.

後処理

  1. extractionThe mixture was then extracted with 50 ml of water
  2. extractionthe product was extracted with ethyl acetate
  3. dry with materialAfter drying the organic phase over sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ad0cb22618c14d2a9255bd81c545f040
出典データセット
uspto-grants-2009_03
特許番号
US07501440B2

反応ノート

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