2-Chloro-5-nitrobenzenesulfonamide → 2-Cyclopropylamino-5-nitrobenzenesulphonamide

HRID 17838

反応式

HRID 17838 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:13])=[O:12].[CH:15]1([NH2:18])[CH2:17][CH2:16]1>O1CCOCC1>[CH:15]1([NH:18][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[S:11]([NH2:14])(=[O:13])=[O:12])[CH2:17][CH2:16]1

参加物

4

反応物 2

HCID 667842-Chloro-5-nitrobenzenesulfonamideHCID 69828Cyclopropylamine

生成物 1

HCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

後処理

  1. additionabove is introduced into a hermetically closed vessel
  2. additioncontaining
  3. customAfter this time period, the solvent and the reagent are removed
  4. concentrationby concentrating under reduced pressure
  5. filtrationis collected by filtration
  6. washwashed with methanol
  7. customdried

出典と根拠

ORDレコード
ord-cc7cdf4d90fc4c72980716ddfe9808c6
出典データセット
uspto-grants-2010_06
特許番号
US07741320B2

関連ノート

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