Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 1783964ノート

反応式

HRID 1783964 の反応式
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

参加物

4

反応物 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

生成物 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

後処理

  1. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-d3bbd687e934429f83c1107e159f79da
出典データセット
uspto-grants-2009_03
特許番号
US07501411B2

反応ノート

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