化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 4-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine | HCID 54446139 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (4-Bromopyridin-2-yl)methyl acetate | HCID 45789873 | — |
反応手順
To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07501411B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-0c44e6b863894bd3bbec0160a1725659 |
| 出典メモ | uspto-grants-2009_03 |