Hydrochloric Acid → Urea, (3-methoxyphenethyl)-

HRID 1784062ノート

反応式

HRID 1784062 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][NH2:11])[CH:6]=[CH:7][CH:8]=1.Cl.[O-:13][C:14]#[N:15].[K+]>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][NH:11][C:14]([NH2:15])=[O:13])[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 748663-MethoxyphenethylamineHCID 11378442Potassium cyanate

生成物 1

HCID 3052719Urea, (3-methoxyphenethyl)-収率 83.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

To a solution of 2-(3-methoxy-phenyl)-ethylamine (1) (50.0 g, 331 mmol) and concentrated HCl (27.6 mL) in water (350 mL), potassium cyanate (28.2 g, 348 mmol) was added and stirred at 50° C. for 2 hours, then at room temperature for 2 days. Formed precipitate was collected by filtration. The solid was washed with water and dried under reduced pressure to give the title compound (53.4 g, 83%). MS (ESI) (M+H)+ 195.

後処理

  1. waitat room temperature for 2 days
  2. customFormed precipitate
  3. filtrationwas collected by filtration
  4. washThe solid was washed with water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-9d805015ed7f431bbc8d0c72fbb7b28f
出典データセット
uspto-grants-2009_03
特許番号
US07501512B2

反応ノート

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