5-Bromo-2H-1,3-benzodioxol-4-ol → 4-(6-Bromo-2,3-methylenedioxyphenoxy)-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline

HRID 1784103

反応式

HRID 1784103 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:25]#[N:26].[Br:27][C:28]1[C:33]([OH:34])=[C:32]2[O:35][CH2:36][O:37][C:31]2=[CH:30][CH:29]=1>>[Br:27][C:28]1[C:33]([O:34][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:25]#[N:26])=[C:32]2[O:35][CH2:36][O:37][C:31]2=[CH:30][CH:29]=1

参加物

3

反応物 2

HCID 110530945-Bromo-2H-1,3-benzodioxol-4-olHCID 117491774-Chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

生成物 1

HCID 179805694-(6-Bromo-2,3-methylenedioxyphenoxy)-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline収率 52%

実験手順

Using an analogous procedure to that described in Example 14, 4chloro-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline was reacted with 6-bromo-2,3-methylenedioxyphenol to give the title compound as a solid in 52% yield; NMR Spectrum: (DMSOd6 and CF3CO2D) 2.25-2.4 (m, 2H), 2.95 (s, 3H), 3.24-4.0 (m, 8H), 3.48 (m, 2H), 3.98 (s, 3H), 4.35 (m, 2H) 6.02 (s, 1H), 6.08 (s, 1H), 6.92 (d, 1H), 7.25 (d, 1H), 7.6 (d, 2H), 8.9 (s, 1H); Mass Spectrum: M+H+ 555 and 557.

出典と根拠

ORDレコード
ord-3944141735ad4ac9aaabaa3d9eb6575c
出典データセット
uspto-grants-2009_03
特許番号
US07501516B2

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