Sodium Dithionite → 6-Ethoxypyrimidine-2,4,5-triamine

HRID 1784107ノート

反応式

HRID 1784107 の反応式
[N:1]([C:3]1[C:4]([O:11][CH2:12][CH3:13])=[N:5][C:6]([NH2:10])=[N:7][C:8]=1[NH2:9])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:10][C:6]1[N:5]=[C:4]([O:11][CH2:12][CH3:13])[C:3]([NH2:1])=[C:8]([NH2:9])[N:7]=1

参加物

4

反応物 2

HCID 24489Sodium Dithionite2 回HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamine

生成物 1

HCID 135414226-Ethoxypyrimidine-2,4,5-triamine収率 61.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To a suspension of the compound of example 3 (7.12 g, 38.9 mmoles) in water (150 ml) at 60° C. was added sodium dithionite (46.7 mmol, 8.12 g). Additional sodium dithionite was added till the pink colour completely dis-appeared and a yellow solution was formed. The solution was stirred at 60° C. for another 4 hours. Water was evaporated and the resulting residue was precipitated from a small amount of water, providing the title compound as a yellow powder (4.02 g, yield 61%). Spectral data are identical with literature data (W. Pfleiderer et al. cited supra).

後処理

  1. customa yellow solution was formed
  2. customWater was evaporated
  3. customthe resulting residue was precipitated from a small amount of water

出典と根拠

ORDレコード
ord-0e0e8be0a02f4c19bf09fd9226c5895a
出典データセット
uspto-grants-2009_03
特許番号
US07501513B2

反応ノート

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