Dimethyl Sulfoxide → (4-Chlorophenyl)(oxo)acetaldehyde

HRID 1784674

反応式

HRID 1784674 の反応式
CS(C)=[O:3].[Cl:5][C:6]1[CH:15]=[CH:14][C:9]([C:10](=[O:13])[CH2:11]Br)=[CH:8][CH:7]=1>O>[Cl:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([CH:11]=[O:3])=[O:13])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 679Dimethyl SulfoxideHCID 68303p-Chlorophenacyl bromide

生成物 1

HCID 269588(4-Chlorophenyl)(oxo)acetaldehyde収率 50%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dimethyl sulfoxide (60 ml) solution of 4-chlorophenacylbromide (11.11 g, 65.9 mmol) and water (1.7 ml) were stirred. The solution was extracted with ethyl acetate 3 times and washed with water twice and brine and then dried over sodium sulfate. After removal of the solvent, the residue was washed with hexane-ethyl acetate and dried to give 4-chlorophenylglyoxal (4.43 g, 50%).

後処理

  1. extractionThe solution was extracted with ethyl acetate 3 times
  2. washwashed with water twice
  3. dry with materialbrine and then dried over sodium sulfate
  4. customAfter removal of the solvent
  5. washthe residue was washed with hexane-ethyl acetate
  6. customdried

出典と根拠

ORDレコード
ord-1633c9ffe56c4fc4b75471ceff8591df
出典データセット
uspto-grants-2009_03
特許番号
US07504411B2

関連ノート

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