Hydrochloric Acid → (S)-2-(4-(N,N-dimethylamino)phenyl)piperazine trihydrochloride

HRID 1784689ノート

反応式

HRID 1784689 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C@@H:9]1[C:21]1[CH:26]=[CH:25][C:24]([N:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=1)=O)(C)(C)C.[ClH:30]>ClCCl.C(OCC)(=O)C>[ClH:30].[ClH:30].[ClH:30].[CH3:29][N:27]([C:24]1[CH:23]=[CH:22][C:21]([C@H:9]2[CH2:10][NH:11][CH2:12][CH2:13][NH:8]2)=[CH:26][CH:25]=1)[CH3:28]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 67117424(S)-1,4-di(t-butoxycarbonyl)-2-(4-(N,N-dimethylamino) phenyl)piperazine

生成物 1

HCID 67117392(S)-2-(4-(N,N-dimethylamino)phenyl)piperazine trihydrochloride収率 96%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of (S)-1,4-di(t-butoxycarbonyl)-2-(4-(N,N-dimethylamino) phenyl)piperazine (556 mg, 1.37 mmol) in dichloromethane (4 mL) was added 4 N hydrogen chloride in ethyl acetate (4 mL). After stirring for 8.5 h, the white precipitate was collected and dried in vacuo to afford (S)-2-(4-(N,N-dimethylamino) phenyl)piperazine trihydrochloride (413 mg, 96%) as white crystals.

後処理

  1. customthe white precipitate was collected
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-46722a4ab12e4015b35c2d141eca1c8d
出典データセット
uspto-grants-2009_03
特許番号
US07504411B2

反応ノート

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