Hydrochloric Acid → 6-Amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride
反応式
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=1)[CH2:7][CH2:8][CH2:9][NH:10]C(OC(C)(C)C)=O)[CH3:2].[ClH:26]>C(OCC)(=O)C>[ClH:26].[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=1)[CH2:7][CH2:8][CH2:9][NH2:10])[CH3:2]参加物
4
実験手順
To a solution of 3-(4-Bromo-phenyl)-6-tert-butoxycarbonylamino-hexanoic acid ethyl ester (2.43 g, 6.32 mmol) in ethyl acetate (3 mL) was added 4 N hydrogen chloride in ethyl acetate (6 mL) at room temperature. Removal of the solvent in vacuo after stirring for 30 min afforded 6-Amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride that was used in the next step without further purification.