Potassium Carbonate → 3-(4-Bromophenyl)piperidin-2-one
反応式
Cl.C(OC(=O)[CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)[CH2:8][CH2:9][CH2:10][NH2:11])C.C(=O)([O-])[O-:21].[K+].[K+]>C(O)C>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([CH:7]2[CH2:8][CH2:9][CH2:10][NH:11][C:6]2=[O:21])=[CH:13][CH:14]=1参加物
4
実験手順
A solution of 6-amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride, potassium carbonate (1039 mg, 7.52 mmol) in ethanol (50 ml) was refluxed for 20 hr. Solvent was removed in vacuo after addition of dilute hydrochloric acid and water was added to the residue. Filtration, wash with water and dryness afforded 3-(4-Bromo-phenyl)-piperidin-2-one (1387 mg, 86%, 2 steps).
後処理
- customSolvent was removed in vacuo
- additionafter addition of dilute hydrochloric acid and water
- additionwas added to the residue
- filtrationFiltration
- washwash with water and dryness
出典と根拠
- ORDレコード
- ord-a1fbf437c99243d6ad6d224e40c0c375
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504411B2
反応ノート
読み込み中…