Hydrochloric Acid → 4-(4-Bromophenyl)piperidine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>C(OCC)(=O)C>[ClH:21].[Br:20][C:17]1[CH:18]=[CH:19][C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:15][CH:16]=1参加物
4
実験手順
To a solution of furnished 4-(4-bromophenyl)-piperidine-1-carboxylic acid tert-butyl ester (1114 mg, 3.27 mmol) in ethyl acetate (1 mL) was added 4 N hydrogen chloride in ethyl acetate (2 mL) at room temperature. After stirring for 5 h, solvent was removed in vacuo, and the resulting solid was washed with ethyl acetate and dried in vacuo to afford (4-(4-bromophenyl)-piperidine hydrochloride (884 mg, 98%) as a white solid.
後処理
- customsolvent was removed in vacuo
- washthe resulting solid was washed with ethyl acetate
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-085f94f171c14756b7758395c55c699e
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504411B2
反応ノート
読み込み中…