2-Amino-5-nitropyridine → 3-Methyl-6-nitroimidazo[1,2-a]pyridine

HRID 1784727ノート

反応式

HRID 1784727 の反応式
Br[CH:2]([CH3:5])[CH:3]=O.[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][N:8]=1>C(OCC)(=O)C>[CH3:5][C:2]1[N:8]2[CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:3]=1

参加物

4

反応物 2

HCID 778882-Amino-5-nitropyridineHCID 3506242-Bromopropanal

生成物 1

HCID 218273463-Methyl-6-nitroimidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Operations similar to Production Example 1-(2) were conducted using 2-bromopropionaldehyde and 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, and washed with saturated aqueous sodium hydrogencarbonate solution to provide the title compound as yellow solid.

後処理

  1. customThe solid whereupon obtained
  2. washwashed with saturated aqueous sodium hydrogencarbonate solution

出典と根拠

ORDレコード
ord-08e9c128559343a49cfbb57ed99de03f
出典データセット
uspto-grants-2009_03
特許番号
US07504412B2

反応ノート

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