2-Amino-5-nitropyridine → Methyl 3-methyl-6-nitroimidazo[1,2-a]pyridine-2-carboxylate
反応式
Br[CH:2]([CH3:9])[C:3](=O)[C:4]([O:6][CH3:7])=[O:5].[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][N:12]=1>C(OCC)(=O)C>[CH3:9][C:2]1[N:12]2[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:11]2=[N:10][C:3]=1[C:4]([O:6][CH3:7])=[O:5]参加物
4
実験手順
Operations similar to Production Example 1-(2) were conducted using methyl 3-bromo-2-oxobutanoate and 2-amino-5-nitropyridine. The resulting solid was suspended in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution and purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to provide the title compound as yellow crystals.
後処理
- washwashed with saturated aqueous sodium hydrogencarbonate solution
- custompurified by silica gel column chromatography (hexane/ethyl acetate=2/1)
出典と根拠
- ORDレコード
- ord-46262c6d7e1642fcbad221c17aa8a3f8
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504412B2
反応ノート
読み込み中…