[[(3-Nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester → 3-(3-Aminophenyl)imidazolidine-2,4-dione

HRID 1785310ノート

反応式

HRID 1785310 の反応式
CO[C:3](=[O:18])[CH2:4][NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)=[O:7]>Cl.CC(C)=O>[NH2:15][C:11]1[CH:10]=[C:9]([N:8]2[C:3](=[O:18])[CH2:4][NH:5][C:6]2=[O:7])[CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 1

HCID 10934009[[(3-Nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester

生成物 1

HCID 246884373-(3-Aminophenyl)imidazolidine-2,4-dione収率 85.2%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒

実験手順

A suspension of [[[(3-nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester (6.9 g, 27 mmol) in 6N aqueous hydrochloride solution (40 mL) and acetone (20 mL) was stirred at reflux overnight. The resulting solution was cooled and concentrated. The resulting yellowish suspension was filtered and the filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL), and air-dried to afford the title compound (4.4 g).

後処理

  1. temperatureat reflux overnight
  2. temperatureThe resulting solution was cooled
  3. concentrationconcentrated
  4. filtrationThe resulting yellowish suspension was filtered
  5. washthe filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL)
  6. customair-dried

出典と根拠

ORDレコード
ord-79780408d8904b6aa7c78e70c80f72ef
出典データセット
uspto-grants-2009_03
特許番号
US07504410B2

反応ノート

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