Acetic Acid → 1-(3-Bromophenyl)-1-methylethylamine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11]C(=O)CCl)([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.NC(N)=S.C(O)(=O)C.O>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:9])[CH3:10])[CH:5]=[CH:6][CH:7]=1参加物
6
実験手順
The mixture of N-[1-(3-bromo-phenyl)-1-methyl-ethyl]-2-chloro-acetamide (1.0 g, 3.5 mmol), thiourea (0.32 g, 4.2 mmol), acetic acid (1.5 mL) in ethanol (7 mL) was heated to reflux for 10 h and brought to room temperature. Water was added to the mixture until a precipitate was formed which was filtered. The filtrate was made basic pH 7-8 with 15% NaOH. The product was extracted with ethyl acetate and concentrated to afford a yellow solid. M+1=214.
後処理
- temperaturewas heated
- temperatureto reflux for 10 h
- custombrought to room temperature
- customwas formed which
- filtrationwas filtered
- extractionThe product was extracted with ethyl acetate
- concentrationconcentrated
- customto afford a yellow solid
出典と根拠
- ORDレコード
- ord-c93c2c43beef47f48b7d8aba95b9eaec
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504403B2
反応ノート
読み込み中…