Magnesium → 3-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1785455ノート

反応式

HRID 1785455 の反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]([CH3:16])=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:14])[CH3:13])[CH:7]=1.[Mg]>CO>[CH3:1][O:2][C:3](=[O:17])[CH:4]([CH3:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:13])[CH3:14])[CH:7]=1

参加物

4

反応物 2

HCID 5462224MagnesiumHCID 690673703-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester

生成物 1

HCID 575931893-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The mixture of 3-[3-(1-amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester (2.0 g, 8.6 mmol), magnesium (0.63 g, 25.8 mmol) in methanol was heated to reflux for 3 h until the starting material was consumed. The mixture was brought to room temperature, filtered and the filtrate was concentrated. The residue obtained was washed with saturated NH4Cl, brine, dried over magnesium sulfate and concentrated.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 3 h until the starting material
  3. customwas consumed
  4. customwas brought to room temperature
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated
  7. customThe residue obtained
  8. washwas washed with saturated NH4Cl, brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

出典と根拠

ORDレコード
ord-69ee3bd99eda4cc58d6d1e27af82a7af
出典データセット
uspto-grants-2009_03
特許番号
US07504403B2

反応ノート

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