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m-Toluohydrazide → 3-Methyl-benzoic acid N'-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Toluohydrazide | HCID 83082 | — |
| 反応物 | 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid | HCID 23654019 | — |
| 生成物 | 3-Methyl-benzoic acid N'-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide | HCID 23654550 | 3.8% |
反応手順
In a similar manner as described for Example 53, 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (41 mg, 0.1 mmol) and m-toluic acid hydrazide (15.0 mg, 0.1 mmol, Lancaster) gave 3-Methyl-benzoic acid N′-[4-(3-chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carbonyl]-hydrazide (2.1 mg, 3.8%) as a white solid. MS m/z 548 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07504513B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-a9b9f7be58f945379c7e2def803e8dae |
| 出典メモ | uspto-grants-2009_03 |