4-Bromo-2-fluorobenzaldehyde → 2-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydrol

HRID 1785665ノート

反応式

HRID 1785665 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[O:19])=[C:16]([F:22])[CH:15]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:18]([OH:19])[C:17]1[CH:20]=[CH:21][C:14]([Br:13])=[CH:15][C:16]=1[F:22]

参加物

4

反応物 3

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141、化合物

生成物 1

HCID 638958522-(Trifluoromethyl)-2'-fluoro-4'-bromobenzhydrol

実験手順

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (60 mmol) and 4-bromo-2-fluorobenzaldehyde (54 mmol) using the procedure described for compound (96) (12.3 g, 74%).

出典と根拠

ORDレコード
ord-dc45ad6a8f53427ba076493717fa957c
出典データセット
uspto-grants-2009_03
特許番号
US07504522B2

反応ノート

読み込み中…