Benzaldehyde → 2-(Trifluoromethyl)benzhydrol

反応式

FC(F)(F)C1C=CC=CC=1[Mg]Br.C(=O)C1C=CC=CC=1.[F:21][C:22]([F:39])([F:38])[C:23]1[CH:36]=[C:35](Cl)[CH:34]=[CH:33][C:24]=1[CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:21][C:22]([F:38])([F:39])[C:23]1[CH:36]=[CH:35][CH:34]=[CH:33][C:24]=1[CH:25]([OH:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

反応物 3

HCID 240Benzaldehyde

HCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanol

HCID 178506141HCID 178506141、化合物

生成物 1

HCID 27774012-(Trifluoromethyl)benzhydrol

実験手順

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and benzaldehyde (15 mmol) using the procedure described for compound (96) (3.7 g, 98%).

出典と根拠

ORDレコード: ord-db6a438c9bdf4143a6b901f9fb01f42c
出典データセット: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07504522B2

反応ノート

読み込み中…