1-(Diphenylmethyl)azetidin-3-ol → Isohexane ethyl acetate
反応式
[CH:1](N1[CH2:17][CH:16]([OH:18])C1)([C:8]1C=CC=C[CH:9]=1)[C:2]1[CH:7]=CC=C[CH:3]=1.FC(F)(F)C1C=CC=C[C:22]=1[CH:23]([OH:31])C1C=CC(C)=CC=1.C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC(Cl)=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[C:23]([O:18][CH2:16][CH3:17])(=[O:31])[CH3:22].[CH3:9][CH2:8][CH2:1][CH:2]([CH3:7])[CH3:3]参加物
4
実験手順
This material was prepared from 1-benzhydryl-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)-4′-methylbenzhydrol (149) (15 mmol) using the procedure described for compound (3). Flash column chromatography [SiO2; ethyl acetate-iso-hexane (5:95)] afforded a yellow gum (4.41 g) which was used in the next step without further purification.
出典と根拠
- ORDレコード
- ord-dcf7beab60df4f599652a6124e74a62a
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504522B2
反応ノート
読み込み中…