4-Methoxybenzaldehyde → 2-(Trifluoromethyl)-4'-methoxybenzhydrol

反応式

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[CH:13](=[O:22])[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:13]([OH:22])[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1

参加物

反応物 3

HCID 312444-Methoxybenzaldehyde

HCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanol

HCID 178506141HCID 178506141、化合物

生成物 1

HCID 133090982-(Trifluoromethyl)-4'-methoxybenzhydrol

実験手順

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and p-anisaldehyde (1.86 mL, 15 mmol) using the procedure described for compound (96) (4.34 g, 100%).

出典と根拠

ORDレコード: ord-5308aabd61c14dc5bd84e5dde926ff29
出典データセット: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07504522B2

反応ノート

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