1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

HRID 1785707ノート

反応式

HRID 1785707 の反応式
[CH:1]([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:37])([F:36])[C:21]1[CH:35]=[CH:34][CH:33]=[CH:32][C:22]=1[CH:23](O)[C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1.C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC(Cl)=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][CH:16]([O:18][CH:23]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[C:22]2[CH:32]=[CH:33][CH:34]=[CH:35][C:21]=2[C:20]([F:37])([F:36])[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 3304481-(Diphenylmethyl)azetidin-3-olHCID 49963912(4-Fluorophenyl)[2-(trifluoromethyl)phenyl]methanolHCID 689038181-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidine

生成物 1

HCID 689032081-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

実験手順

This material was prepared from 1-benzhydryl-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)-4′-fluorobenzhydrol (160) (15 mmol) using the procedure described for compound (3). After basic aqueous workup, the crude product was used in the next step without further purification.

後処理

  1. customAfter basic aqueous workup, the crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-62fbb1e06dcc4cf48b8456677bf4b467
出典データセット
uspto-grants-2009_03
特許番号
US07504522B2

反応ノート

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