4-(Methylsulfonyl)benzaldehyde → 2-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrol

HRID 1785715ノート

反応式

HRID 1785715 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[CH3:13][S:14]([C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1)(=[O:16])=[O:15].FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:21]([OH:22])[C:20]1[CH:19]=[CH:18][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[CH:24][CH:23]=1

参加物

4

反応物 3

HCID 2203764-(Methylsulfonyl)benzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141、化合物

生成物 1

HCID 689024622-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrol収率 108.6%

実験手順

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (14.5 mmol) and 4-(methylsulfonyl)benzaldehyde (2.68 g, 13.8 mmol) using the procedure described for compound (96). The product was obtained as an amber gum (4.95 g, 100%).

出典と根拠

ORDレコード
ord-dde7f526db1f4046aa203d05de1beca4
出典データセット
uspto-grants-2009_03
特許番号
US07504522B2

反応ノート

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