Phosphorus oxychloride → Methyl 4-(6-chloropyridin-3-yl)benzoate

HRID 1785814ノート

反応式

HRID 1785814 の反応式
O[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178497536HCID 178497536、化合物

生成物 1

HCID 22730372Methyl 4-(6-chloropyridin-3-yl)benzoate

実験手順

A solution of Example 252E (1.2 g, 5 mmol) in POCl3 (30 mL) was heated to reflux for 30 minutes. The excess POCl3 was removed under vacuum and the remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes to provide the desired product. MS (ESI) m/e 248 (M+H)+.

後処理

  1. temperatureto reflux for 30 minutes
  2. customThe excess POCl3 was removed under vacuum
  3. customthe remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-ce4250fbd35d41899f315675d0e98526
出典データセット
uspto-grants-2009_03
特許番号
US07504512B2

反応ノート

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