Trimethylsilyldiazomethane → 2-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

HRID 1786046ノート

反応式

HRID 1786046 の反応式
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][CH2:14][OH:15])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][Si](C=[N+]=[N-])(C)C>CO>[CH3:16][O:11][C:10](=[O:12])[CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:13][CH2:14][OH:15]

参加物

4

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 41186272-(((Tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid

生成物 1

HCID 68578092-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-tert-Butoxycarbonylamino-4-hydroxy-butyric acid (0.79 g, 3.6 mmol) was dissolved in 15 ml methanol at room temperature and (trimethylsilyl)diazomethane (2M solution in hexane) was added till solution become yellow. The mixture was concentrated down to afford crude 2-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester.

後処理

  1. concentrationThe mixture was concentrated down

出典と根拠

ORDレコード
ord-5ce92dc187844cc28977b7bd81bea19d
出典データセット
uspto-grants-2009_03
特許番号
US07504508B2

反応ノート

読み込み中…