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2-Methoxyacetohydrazide → 9-Chloro-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxyacetohydrazide | HCID 2759532 | — |
| 反応物 | Ethyl 4-chloro-2-cyanophenylcarbamate | HCID 21779762 | — |
| 生成物 | 9-Chloro-2-methoxymethyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one | HCID 136347869 | 88% |
反応手順
As described for example 1a) (4-chloro-2-cyano-phenyl)-carbamic acid ethyl ester (71.0 g, 316 mmol) using methoxymethyl-carboxylic acid hydrazide instead of cyclopropane-carboxylic acid hydrazide, was converted to the title compound (73.9 g, 88%) which was obtained as a yellow solid. MS: m/e=264.9 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07507729B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-966f88043c0a4b97b0f02e8322057c1f |
| 出典メモ | uspto-grants-2009_03 |