p-Anisoyl chloride → 4-Methoxy-N-[1-({[2-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]amino}carbonyl)cyclopropyl]benzamide

HRID 17863

反応式

HRID 17863 の反応式
Cl.[NH2:2][C:3]1([C:6]([NH:8][CH2:9][CH2:10][C:11]2[N:12]([CH3:30])[C:13](=[O:29])[C:14]3[C:19]([C:20]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:18][C:17]([O:27][CH3:28])=[CH:16][CH:15]=3)=[O:7])[CH2:5][CH2:4]1.C(N(CC)CC)C.[CH3:38][O:39][C:40]1[CH:48]=[CH:47][C:43]([C:44](Cl)=[O:45])=[CH:42][CH:41]=1>CN(C)C=O>[CH3:38][O:39][C:40]1[CH:48]=[CH:47][C:43]([C:44]([NH:2][C:3]2([C:6]([NH:8][CH2:9][CH2:10][C:11]3[N:12]([CH3:30])[C:13](=[O:29])[C:14]4[C:19]([C:20]=3[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:18][C:17]([O:27][CH3:28])=[CH:16][CH:15]=4)=[O:7])[CH2:5][CH2:4]2)=[O:45])=[CH:42][CH:41]=1

参加物

5

反応物 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 684349641-amino-N-[2-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]cyclopropanecarboxamide hydrochloride

生成物 1

HCID 114666314-Methoxy-N-[1-({[2-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]amino}carbonyl)cyclopropyl]benzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 1-amino-N-[2-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]cyclopropanecarboxamide hydrochloride (30 mg, 0.117 mmol) in 3 mL of dimethylformamide was added triethylamine (0.049 mL, 0.35 mmol), followed by 4-(methoxy)benzoyl chloride (24 mg, 0.14 mmol). After 3 days, the mixture was concentrated in vacuo. Purification by preparative reversed phase HPLC provided the titled compound. ESI+MS: 526.0 [M+H]+.

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customPurification by preparative reversed phase HPLC

出典と根拠

ORDレコード
ord-b0d616ffade642d8850dc2e3ab840ee7
出典データセット
uspto-grants-2010_06
特許番号
US07741322B2

関連ノート

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